The NANT Cancer Vaccine applies multiple aspects of cancer therapy utilizing therapeutic agents to transition cancer cells from an escape phase back to an equilibrium or elimination phase. These therapeutic agents are synergistically tailored to a patient’s tumor and intended to act in a coordinated manner to modulate the tumor microenvironment to reduce immune suppression, increase stress and damage recognition signals in the tumor, induce and enhance innate and adaptive immune responses, and generate immune memory in order to achieve improved response rates and patient outcomes.